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Transdermal permeation of neutral molecules by skin electroporation

1998; Elsevier BV; Volume: 54; Issue: 3 Linguagem: Inglês

10.1016/s0168-3659(97)00146-6

1873-4995

Rita Vanbever, Marie-Ange Leroy, Véronique Préat,

Transgenic Plants and Applications

Electroporation of skin has recently been shown to enhance transport of charged molecules across skin by up to four orders of magnitude. This study demonstrates that high-voltage pulses can also increase transdermal permeation of two neutral model solutes, i.e. mannitol and water, up to 100-fold. The elevated flux results from the persistent increase in skin permeability following electroporation, rather than from electro-osmosis during pulsing. Control on transport was achieved by controlling the electrical parameters of the pulse, i.e. the pulse voltage, time constant and number.