Synthesis and release behavior of methotrexate from Fe3O4/PLA–PEG core/shell nanoparticles with high saturation magnetization
2013; Elsevier BV; Volume: 108; Linguagem: Inglês
10.1016/j.matlet.2013.06.108
ISSN1873-4979
AutoresFenghua Chen, Taonan Zhao, Qingtao Chen, Lifeng Han, Shaoming Fang, Zhijun Chen,
Tópico(s)biodegradable polymer synthesis and properties
ResumoA magnetic targeted drug delivery system with a high Ms value was prepared based on Fe3O4/PLA core/shell nanoparticles for the controlled release methotrexate (MTX). To endow the carrier with hydrophilicity and biocompatibility, an effective surface modification method to graft polyethylene glycol (PEG) was also proposed. The obtained nanocomposites were characterized by TEM, FTIR, XRD, and VSM. The MTX-loading efficiency and drug release behavior of the system were determined by UV–vis spectrometer. The results showed that the MTX displayed a pH-dependent releasing behavior and the existence of PEG would slow down the release rate. Additionally, a cell viability assay was also carried out to evaluate the biocompatibility of Fe3O4/PLA–PEG and the anticancer activities of prepared Fe3O4/PLA–PEG–MTX.
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