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Metazoan replication-dependent histone mRNAs: a distinct set of RNA polymerase II transcripts

2005; Elsevier BV; Volume: 17; Issue: 3 Linguagem: Inglês

10.1016/j.ceb.2005.04.010

1879-0410

William F. Marzluff,

Genomics and Chromatin Dynamics

Metazoan replication-dependent histone mRNAs are the only eukaryotic mRNAs that lack polyA tails. The genes for the five histone proteins have remained physically linked during evolution. Expression of histone mRNAs and histone proteins requires a unique set of factors, and may be coordinated by association of the histone genes with Cajal bodies. Recently several novel factors, including components of the U7 snRNP, as well as proteins involved in regulation of histone gene expression, have been described.