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The Impact of Cyclooxygenase-2 and Vascular Endothelial Growth Factor C Immunoexpression on the Prognosis of Penile Carcinoma

2011; Lippincott Williams & Wilkins; Volume: 187; Issue: 1 Linguagem: Inglês

10.1016/j.juro.2011.09.027

1527-3792

Adriano Augusto Peclat de Paula, Eliane Duarte Motta, Rita de Cássia Gonçalves Alencar, Vera Aparecida Saddi, Rosana Correa da Silva, Gustavo Nogueira Caixeta, J. C. Almeida Netto, Megmar Aparecida dos Santos Carneiro,

Urologic and reproductive health conditions

No AccessJournal of UrologyAdult Urology1 Jan 2012The Impact of Cyclooxygenase-2 and Vascular Endothelial Growth Factor C Immunoexpression on the Prognosis of Penile Carcinoma Adriano Augusto Peclat De Paula, Eliane Duarte Motta, Rita de Cassia Alencar, Vera Aparecida Saddi, Rosana Correa da Silva, Gustavo Nogueira Caixeta, Joaquim Caetano Almeida Netto, and Megmar Aparecida dos Santos Carneiro Adriano Augusto Peclat De PaulaAdriano Augusto Peclat De Paula Onco-Urology Department, Araujo Jorge Hospital, Associaço de Combate ao Cancer em Goiás, Goiânia, Brazil , Eliane Duarte MottaEliane Duarte Motta Pathology Department, Araujo Jorge Hospital, Associaçao de Combate ao Cancer em Goiás, Goiânia, Brazil , Rita de Cassia AlencarRita de Cassia Alencar Pathology Department, Araujo Jorge Hospital, Associaçao de Combate ao Cancer em Goiás, Goiânia, Brazil , Vera Aparecida SaddiVera Aparecida Saddi Genetics Department, Pontificius Catholic University of Goiás, Goiânia, Brazil , Rosana Correa da SilvaRosana Correa da Silva Pathology Department, Araujo Jorge Hospital, Associaçao de Combate ao Cancer em Goiás, Goiânia, Brazil , Gustavo Nogueira CaixetaGustavo Nogueira Caixeta Pathology Department, Araujo Jorge Hospital, Associaçao de Combate ao Cancer em Goiás, Goiânia, Brazil , Joaquim Caetano Almeida NettoJoaquim Caetano Almeida Netto Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, Brazil , and Megmar Aparecida dos Santos CarneiroMegmar Aparecida dos Santos Carneiro Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, Brazil View All Author Informationhttps://doi.org/10.1016/j.juro.2011.09.027AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We assessed the influence of cyclooxygenase-2 and vascular endothelium growth factor-C immunoexpression on groin metastasis and cancer survival, and their association with histological variables in patients with penile carcinoma. Materials and Methods: We evaluated the histological and cyclooxygenase-2/vascular endothelium growth factor-C immunohistochemical profiles of patients with penile carcinoma treated at a single institution between 2001 and 2008. Univariate and multivariate analysis was done to determine the impact of histological and immunohistochemical markers on the risk of inguinal metastasis and on cancer survival. Survival analysis of relevant variables was also done. Results: Of the 127 patients enrolled 76 and 30 had positive cyclooxygenase-2 and vascular endothelium growth factor-C immunoexpression, respectively. Univariate analysis identified an association between vascular endothelium growth factor-C immunoexpression and groin metastasis, and certain histological variables. Logistic regression showed that high tumor grade, Jackson stage and vascular endothelium growth factor-C immunoexpression were independent predictors of inguinal metastasis. Cancer survival was only influenced by advanced Jackson stage and groin metastasis. Conclusions: Findings suggest that vascular endothelium growth factor-C expression may help identify patients with an unfavorable clinical course of penile carcinoma. Cyclooxygenase-2 did not alter the risk of groin metastasis or cancer death. Inguinal disease and advanced Jackson stage were independent prognostic factors for worse cancer survival. References 1 : Systematic review of human papillomavirus prevalence in invasive penile cancer. Cancer Causes Control2009; 20: 449. Google Scholar 2 : . Lyon: IARC2002: 1. Google Scholar 3 : Penile cancer: epidemiology, pathogenesis and prevention. World J Urol2009; 27: 141. Google Scholar 4 : Breast cancer prognostic classification in the molecular era: the role of histological grade. Breast Cancer Res2010; 12: 207. Google Scholar 5 : Analyses of 200 lymphadenectomies in patients with penile carcinoma. J Urol1991; 146: 330. 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Google Scholar © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 1January 2012Page: 134-140 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.Keywordscarcinomapenile neoplasmsvascular endothelial growth factor Cpeniscyclooxygenase 2MetricsAuthor Information Adriano Augusto Peclat De Paula Onco-Urology Department, Araujo Jorge Hospital, Associaço de Combate ao Cancer em Goiás, Goiânia, Brazil More articles by this author Eliane Duarte Motta Pathology Department, Araujo Jorge Hospital, Associaçao de Combate ao Cancer em Goiás, Goiânia, Brazil More articles by this author Rita de Cassia Alencar Pathology Department, Araujo Jorge Hospital, Associaçao de Combate ao Cancer em Goiás, Goiânia, Brazil More articles by this author Vera Aparecida Saddi Genetics Department, Pontificius Catholic University of Goiás, Goiânia, Brazil More articles by this author Rosana Correa da Silva Pathology Department, Araujo Jorge Hospital, Associaçao de Combate ao Cancer em Goiás, Goiânia, Brazil More articles by this author Gustavo Nogueira Caixeta Pathology Department, Araujo Jorge Hospital, Associaçao de Combate ao Cancer em Goiás, Goiânia, Brazil More articles by this author Joaquim Caetano Almeida Netto Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, Brazil More articles by this author Megmar Aparecida dos Santos Carneiro Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, Brazil More articles by this author Expand All Advertisement PDF downloadLoading ...