Nephrogenic Diabetes Insipidus Associated with Foscarnet Treatment of Cytomegalovirus Retinitis
1990; American College of Physicians; Volume: 112; Issue: 12 Linguagem: Inglês
10.7326/0003-4819-112-12-955
ISSN1539-3704
Autores Tópico(s)Glycogen Storage Diseases and Myoclonus
ResumoBrief Reports15 June 1990Nephrogenic Diabetes Insipidus Associated with Foscarnet Treatment of Cytomegalovirus RetinitisRobert V. Farese Jr., MD, Morris Schambelan, MD, Harry Hollander, MD, Suzan Stringari, RN, MSN, Mark A. Jacobson, MDRobert V. Farese Jr., MDSearch for more papers by this author, Morris Schambelan, MDSearch for more papers by this author, Harry Hollander, MDSearch for more papers by this author, Suzan Stringari, RN, MSNSearch for more papers by this author, Mark A. Jacobson, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-12-955 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNephrogenic diabetes insipidus occurs both as a rare X-linked genetic disorder and, more commonly, as a complication of therapy with lithium carbonate and various other drugs (1). We report a case of a patient with the acquired immunodeficiency syndrome (AIDS) who developed nephrogenic diabetes insipidus as a complication of treatment of cytomegalovirus (CMV) retinitis with foscarnet (trisodium phosphonoformate).Case ReportA 37-year-old homosexual man was hospitalized at the General Clinical Research Center at San Francisco General Hospital for evaluation of polydipsia and polyuria. He had been diagnosed with AIDS more than 2.5 years earlier when he developed Kaposi sarcoma. Subsequently,...References1. SingerForrest IJ. Drug-induced states of nephrogenic diabetes insipidus. Kidney Int. 1976;10:82-95. CrossrefMedlineGoogle Scholar2. JacobsonO'DonnellMills MJJ. Foscarnet treatment of cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome. Antimicrob Agents Chemother. 1989;33:736-41. CrossrefMedlineGoogle Scholar3. MillerDalakosMosesFellermanStreeten MTAHD. Recognition of partial defects in antidiuretic hormone secretion. Ann Intern Med. 1970;73:721-9. LinkGoogle Scholar4. WalmsleyChewRead SES. Treatment of cytomegalovirus retinitis with trisodium phosphonoformate hexahydrate (foscarnet). J Infect Dis. 1988;157:569-72. CrossrefMedlineGoogle Scholar5. KlintmalmLonnqvistOberg GBB. Intravenous foscarnet for the treatment of severe cytomegalovirus infection in allograft recipients. Scand J Infect Dis. 1985;17:157-63. CrossrefMedlineGoogle Scholar6. RingdenLonnqvistPaulin OBT. Pharmacokinetics, safety and preliminary clinical experiences using foscarnet for the treatment of cytomegalovirus infections in bone marrow and renal transplant recipients. J Antimicrob Chemother. 1986;17:373-87. CrossrefMedlineGoogle Scholar7. SjovallBergdahlMovinOgenstadSaarimaki JSGSM. Pharmacokinetics of foscarnet and distribution to cerebrospinal fluid after intravenous infusion in patients with human immunodeficiency virus infection. Antimicrob Agents Chemother. 1989;33:1023-31. CrossrefMedlineGoogle Scholar8. Robertson G. Diagnosis of diabetes insipidus. In: Czernichow AP, Robinson A, eds. Diabetes Insipidus in Man: Frontiers of Hormone Research, v 13. New York: Karger; 1985:127-55. CrossrefGoogle Scholar9. YusufiSzczepanska-KonkelKempsonMcAteerDousa AMSJT. Inhibition of human renal epithelial Na+/Pi cotransport by phosphonoformic acid. Biochem Biophys Res Commun. 1986;139:679-86. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Robert V. FareseJr., MD; Morris Schambelan, MD; Harry Hollander, MD; Suzan Stringari, RN, MSN; Mark A. Jacobson, MDFrom San Francisco General Hospital, San Francisco, California; and AIDS Clinic, University of California San Francisco, San Francisco, California. For current author addresses, see end of text. 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