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A common polymorphism in the renin angiotensin system is associated with differential outcome of antihypertensive pharmacotherapy prescribed to Brazilian older women

2008; Elsevier BV; Volume: 396; Issue: 1-2 Linguagem: Inglês

10.1016/j.cca.2008.07.002

1873-3492

Clayton Franco Moraes, Elias Rosa de Souza, Vinícius Carius de Souza, Eloá Fátima Ferreira de Medeiros, Thiago Franco Gonçalves, Juliana Oliveira de Toledo Nóbrega, Mauro Karnikowski, Lucy Gomes, Margô Gomes de Oliveira Karnikowski, Cláudio Córdova, Otávio Tolêdo Nóbrega,

Blood Pressure and Hypertension Studies

Since variations on the renin angiotensin (RA) system tend to exert effects on blood pressure, we investigated the association of the common ACE and AT1R polymorphisms with response to a multivariate pharmacotherapy.This prospective study involved 169 hypertensive, community-dwelling older women. Genotypes were obtained by length analysis or direct sequencing of PCR products. Blood pressure-lowering pharmacotherapy was conducted according to current Brazilian Guidelines on Hypertension.Genotype frequencies were in agreement to the Hardy-Weinberg equilibrium. Interventions were found to represent actual hypertension-management practices in Brazil, and accounted for a significant reduction in both systolic (P<0.001) and diastolic (P 0.05). Nonetheless, the clinical result varied according to the ACE alleles since mean systolic pressure was roughly 10 mm Hg higher in insertion (I) homozygotes than in the deletion (D) counterparts either in baseline (P=0.001) and endpoint (P=0.010).The outcome of the antihypertensive pharmacotherapy advocated by national guidelines was significantly influenced by the ACE I/D polymorphism but not by the AT1R 1166 A/C polymorphism among postmenopausal women.