Sequential Staudinger/Pictet–Spengler cyclization strategy for the construction of tetrahydroisoquinolines of the bioxalomycin and ecteinascidin family of alkaloids
2001; Elsevier BV; Volume: 42; Issue: 4 Linguagem: Inglês
10.1016/s0040-4039(00)02015-3
ISSN1873-3581
AutoresBrad Herberich, Masahiko Kinugawa, Alfredo Vázquez, Robert M. Williams,
Tópico(s)Marine Sponges and Natural Products
ResumoThe use of the Staudinger ketene–imine β-lactam-forming cycloaddition reaction and the Pictet–Spengler cyclization reaction in sequence, has been used to prepare highly functionalized tetrahydroisoquinolines relevant to the bioxalomycin and ecteinascidin family of antitumor alkaloids.
Referência(s)