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Epidermodysplasia verruciformis-like eruption complicating human immunodeficiency virus infection

1998; Oxford University Press; Volume: 139; Issue: 1 Linguagem: Inglês

10.1046/j.1365-2133.1998.02328.x

1365-2133

Barzegar, C. Paul, Saiag, Cassenot, H. Bachelez, Autran, Guy Gorochov, Petit, Dubertret,

Viral-associated cancers and disorders

Three human immunodeficiency virus (HIV)-infected patients presented with disseminated pityriasis versicolor-like skin lesions. Histological examination showed features characteristic of epidermodysplasia verruciformis (EV). Hybridization studies demonstrated the presence of human papillomavirus (HPV) type 5 (HPV5) DNA in two patients and HPV20 in one. A relative increase in CD8 +, CD57 + cells, which are known to inhibit cell-mediated cytolysis, was observed in all patients. HLA-DQB 0301 haplotype, which has been associated with EV, was detected in two patients. The findings suggest that infection with EV-associated HPV types can complicate HIV infection. Both cellular immune defects and a hitherto unknown genetic background might explain the occurrence of EV in HIV-infected patients.