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Transforming growth factor‐β: crossroad of glucocorticoid and bleomycin regulation of collagen synthesis in lung fibroblasts

1999; Wiley; Volume: 7; Issue: 3 Linguagem: Inglês

10.1046/j.1524-475x.1999.00133.x

1524-475X

Arti Shukla, Natalie T. Meisler, Kenneth R. Cutroneo,

Neonatal Respiratory Health Research

Fibrosis is a consequence of injury which is characterized by accumulation of excess collagen and other extracellular matrix components, resulting in the destruction of normal tissue architecture and function. Transforming growth factor‐β, a potent wound healing agent, has also been shown to be an agent that can produce fibrosis because it is a potent stimulator of collagen synthesis. Both glucocorticoids and bleomycin have recently been shown to affect collagen synthesis in opposite directions, by utilizing a common pathway of involving transforming growth factor‐β activator protein binding to the transforming growth factor‐β element. This article presents a mechanistic overview of collagen synthesis regulation by glucocorticoids and bleomycin through the transforming growth factor‐β pathway.