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Accelerated Induction of Bladder Cancer in Patched Heterozygous Mutant Mice

2004; American Association for Cancer Research; Volume: 64; Issue: 6 Linguagem: Inglês

10.1158/0008-5472.can-03-2031

1538-7445

Sahar Hamed, Hélène LaRue, Hélène Hovington, Johanne Girard, Lucie Jeannotte, Éva Latulippe, Yves Fradet,

Cancer and Skin Lesions

Abstract The PATCHED (PTC) gene is recognized as a tumor suppressor in basal cell carcinoma. Mapping of a minimal region of deletion at 9q22.3 and observation of a decreased PTC expression in superficial papillary bladder tumors led us to hypothesize that it could also be involved in this cancer. To further investigate this hypothesis, we submitted Ptc+/− heterozygous mutant mice and their wild-type littermates to chemical carcinogenesis by adding N-butyl-N-(4-hydroxybutyl) nitrosamine to their drinking water. Preneoplastic and neoplastic changes were observed significantly earlier in the Ptc+/− than in the wild-type mice. Our data support the hypothesis of Ptc acting as a tumor suppressor gene in bladder cancer.