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Determinants of salivary cotinine level: a population-based study in Brazil

2007; UNIVERSIDADE DE SÃO PAULO; Volume: 41; Issue: 6 Linguagem: Inglês

10.1590/s0034-89102006005000048

1518-8787

Valeska Carvalho Figueiredo, Moysés Szklo, André Salem Szklo, Neal L. Benowitz, José Azevedo Lozana, Letícia Casado, Elaine Masson, Jonathan M. Samet,

Indoor Air Quality and Microbial Exposure

A cross-sectional population-based study was conducted to assess, in active smokers, the relationship of number of cigarettes smoked and other characteristics to salivary cotinine concentrations.A random sample of active smokers aged 15 years or older was selected using a stepwise cluster sample strategy, in the year 2000 in Rio de Janeiro, Brazil. The study included 401 subjects. Salivary cotinine concentration was determined using gas chromatography with nitrogen-phosphorus detection. A standard questionnaire was used to collect demographic and smoking behavioral data. The relation between the number of cigarettes smoked in the last 24h and cotinine level was examined by means of a nonparametric fitting technique of robust locally weighted regression.Significantly (p 40 ng/mL per cigarette were excluded.There was found a positive association between self-reporting smoking five minutes after waking up, and inhaling more than (1/2) the time are consistent and higher cotinine levels. These can be markers of dependence and higher nicotine intake. Salivary cotinine proved to be a useful biomarker of recent smoking and can be used in epidemiological studies and smoking cessation programs.