Thermo responsive DNA/Polymer Conjugate for Intelligent Antisense Strategy
2003; Oxford University Press; Volume: 32; Issue: 3 Linguagem: Inglês
10.1246/cl.2003.266
ISSN1348-0715
AutoresMasaharu Murata, Wataru Kaku, Takahisa Anada, Nobuaki Soh, Yoshiki Katayama, Mizuo Maeda,
Tópico(s)RNA Interference and Gene Delivery
ResumoAbstract The conjugate between 20-mer antisense oligodeoxynucleotides (ODN) and thermo-responsive polymer, poly(N-isopropylacrylamide) (PNIPAAm), was prepared. Hybridization reaction between the conjugate and their target RNA was modulated by conformational change of polymer moiety depending on temperature condition.
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