Portal de Periódicos da CAPES

3D printed microfluidic devices with integrated valves

2015; American Institute of Physics; Volume: 9; Issue: 1 Linguagem: Inglês

10.1063/1.4905840

1932-1058

Chad I. Rogers, Kamran Qaderi, Adam T. Woolley, Gregory P. Nordin,

Microfluidic and Bio-sensing Technologies

We report the successful fabrication and testing of 3D printed microfluidic devices with integrated membrane-based valves. Fabrication is performed with a low-cost commercially available stereolithographic 3D printer. Horizontal microfluidic channels with designed rectangular cross sectional dimensions as small as 350 μm wide and 250 μm tall are printed with 100% yield, as are cylindrical vertical microfluidic channels with 350 μm designed (210 μm actual) diameters. Based on our previous work [Rogers et al., Anal. Chem. 83, 6418 (2011)], we use a custom resin formulation tailored for low non-specific protein adsorption. Valves are fabricated with a membrane consisting of a single build layer. The fluid pressure required to open a closed valve is the same as the control pressure holding the valve closed. 3D printed valves are successfully demonstrated for up to 800 actuations.