A High-Resolution Genetic Map of Mouse Chromosome 5 Encompassing the Reeler (rl) Locus
1994; Elsevier BV; Volume: 23; Issue: 3 Linguagem: Inglês
10.1006/geno.1994.1557
ISSN1089-8646
AutoresMarie‐Claire Beckers, Isabelle Bar, T HUYNHTHU, Christiane Dernoncourt, Ana Lúcia Brunialti Godard, Xavier Montagutelli, Jean‐Louis Guénet, André M. Goffinet,
Tópico(s)RNA Research and Splicing
ResumoUsing interspecific crosses between BALB/c and Mus spretus (SEG) mice, the murine reeler (rl) gene was mapped to the proximal region of chromosome 5 between the hepatocyte growth factor gene (Hgf) and the D5Mit66 microsatellite. The following order was defined: (centromere)-Cchl2a/Hgf-D5Mit1-D5Nam1/D5-Nam2 -rl/D5Mit61-D5Mit72-Xmv45-Htr5a- Peplb-D5Nam3-D5Mit66. Estimated distances between reeler and the nearest flanking markers D5Nam1 and D5Mit72 are 1.5 and 1.0 cM, respectively (95% confidence level), suggesting that the region could be physically mapped using a manageable number of YAC clones.
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