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Programmed Death of T Cells in HIV-1 Infection

1992; American Association for the Advancement of Science; Volume: 257; Issue: 5067 Linguagem: Inglês

10.1126/science.1352911

1095-9203

Linde Meyaard, Sigrid A. Otto, Richard R. Jonker, M. Janneke Mijnster, René Keet, Frank Miedema,

Cytomegalovirus and herpesvirus research

In human immunodeficiency virus (HIV) infection, functional defects and deletion of antigen-reactive T cells are more frequent than can be explained by direct viral infection. On culturing, both CD4+ and CD8+ T cells from asymptomatic HIV-infected individuals died as a result of programmed cell death (apoptosis). Apoptosis was enhanced by activation with CD3 antibodies. Programmed cell death, associated with impaired T cell reactivity, may thus be responsible for the deletion of reactive T cells that contributes to HIV-induced immunodeficiency.