Thallium-201 single photon emission computed tomography as an indicator of prognosis for patients with lung carcinoma
1997; Wiley; Volume: 80; Issue: 2 Linguagem: Inglês
10.1002/(sici)1097-0142(19970715)80
ISSN1097-0142
AutoresHironori Takekawa, Kazuo Takaoka, Eriko Tsukamoto, Kakuko Kanegae, Frederick W. Miller, Yoshikazu Kawakami,
Tópico(s)Radiomics and Machine Learning in Medical Imaging
ResumoBACKGROUND The uptake of thallium-201 (Tl-201) in malignant tumors is associated with malignant potential (metastatic potential and proliferative activity). The grade of accumulation of Tl-201 in malignant tumors may provide information regarding prognosis. METHODS A Tl-201 single photon emission computed tomography was conducted 120 minutes after intravenous injection of 111 megabecquerel of Tl-201 chloride. The authors calculated the uptake ratio to evaluate the degree of Tl-201 uptake in the primary tumor. This ratio was compared with survival time and other prognostic factors. RESULTS The authors studied 152 patients (125 men and 27 women). The group of patients with the low Tl-201 uptake ratio survived longer than the group of patients with the high Tl-201 uptake ratio (median survival, 58 weeks vs. 33 weeks; P = 0.0138 by the log rank test). The multivariate analysis confirmed that the Tl-201 uptake ratio was an independent prognostic factor for survival. CONCLUSIONS These results suggest that the Tl-201 uptake ratio provides independent and objective prognostic information for patients with lung carcinoma. Cancer 1997; 80:198-203. © 1997 American Cancer Society.
Referência(s)