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Interaction between 5-HT1B receptors and nitric oxide in zebrafish responses to novelty

2014; Elsevier BV; Volume: 588; Linguagem: Inglês

10.1016/j.neulet.2014.12.049

1872-7972

Caio Maximino, Mônica Gomes Lima, Evander de Jesus Oliveira Batista, Karen Renata Herculano Matos Oliveira, Anderson Manoel Herculano,

Physiological and biochemical adaptations

Nitric oxide (NO) and serotonin (5-HT) interact at the molecular and systems levels to control behavioral variables, including agression, fear, and reactions to novelty. In zebrafish, the 5-HT1B receptor has been implicated in anxiety and reactions to novelty, while the 5-HT1A receptor is associated with anxiety-like behavior; this role of the 5-HT1A receptor is mediated by NO. This work investigated whether NO also participates in the mediation of novelty responses by the 5-HT1B receptor. The 5-HT1B receptor inverse agonist SB 224,289 decreased bottom-dwelling and erratic swimming in zebrafish; the effects on bottom-dwelling, but not on erratic swimming, were blocked by pre-treatment with the nitric oxide synthase inhibitor L-NAME. These effects underline a novel mechanism by which 5-HT controls zebrafish reactivity to novel environments, with implications for the study of neotic reactions, exploratory behavior, and anxiety-like states.