Recombinant human tumor necrosis factor α constricts pial arterioles and increases blood-brain barrier permeability in newborn piglets
1992; Elsevier BV; Volume: 148; Issue: 1-2 Linguagem: Inglês
10.1016/0304-3940(92)90823-p
ISSN1872-7972
AutoresP. Megyeri, Csongor S. Ábrahám, Péter Temesvári, József Kovács, Tamás Vas, Christian P. Speer,
Tópico(s)Neonatal and fetal brain pathology
ResumoTumor necrosis factor α (TNFα) plays a significant role in the pathogenesis of central nervous system infections. We investigated the effect of intracisternal injection of recombinant human TNFα (50–50,000 IU) on pial vasoreactivity and blood-brain barrier permeability in newborn piglets. The cytokine administration resulted in arterial vasoconstrictions, blood-brain barrier opening for Na-fluorescein (mol. wt. 376 Da) and increased Na-fluorescein uptake in brain regions examined (parietal and occipital cortex, cerebellum, pons/medulla, periventricular white matter) in a dose-dependent manner. TNFα may be involved in the pathophysiology of neonatal brain injuries.
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