Galanin-like peptide stimulates food intake in the rat
2002; Elsevier BV; Volume: 322; Issue: 1 Linguagem: Inglês
10.1016/s0304-3940(01)02515-0
ISSN1872-7972
AutoresYoshio Matsumoto, Takuya Watanabe, Yuka Adachi, Takashi Itoh, Tetsuya Ohtaki, Haruo Onda, Tsutomu Kurokawa, Osamu Nishimura, Masahiko Fujino,
Tópico(s)Regulation of Appetite and Obesity
ResumoWe have isolated a novel hypothalamic peptide, Galanin-like peptide (GALP), as a ligand for galanin receptor subtype GalR2. To investigate the physiological role of GALP, we examined the effect of the intracerebroventricular administration of GALP and found that GALP induced food intakes. GALP had ten-fold the orexigenic activity of galanin. We also observed the anxiogenic-like behavior after the administration of 1 nmol GALP. These results suggest that GALP is a novel orexigenic and anxiogenic peptide.
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