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Chemical Composition and in vitro Schistosomicidal Activity of the Essential Oil of Plectranthus neochilus Grown in Southeast Brazil

2011; Wiley; Volume: 8; Issue: 11 Linguagem: Inglês

10.1002/cbdv.201100167

1612-1880

Soraya C. Caixeta, Lizandra Guidi Magalhães, Nathalya Isabel de Melo, Kamila A. L. Wakabayashi, Gabriela de Paula Aguiar, Daniela de Paula Aguiar, André L. L. Mantovani, Jacqueline Morais Alves, Pollyanna Francielli de Oliveira, Denise Crispim Tavares, Milton Groppo, Vanderlei Rodrigues, Wilson Roberto Cunha, Rodrigo Cássio Sola Veneziani, Ademar Alves da Silva Filho, Antônio Eduardo Miller Crotti,

Helminth infection and control

Abstract The chemical composition and the in vitro schistosomicidal effects of the essential oil of Plectranthus neochilus (PN‐EO) grown in Southeast Brazil was studied. β ‐Caryophyllene ( 1 ; 28.23%), α ‐thujene ( 2 ; 12.22%), α ‐pinene ( 3 ; 12.63%), β ‐pinene ( 4 ; 6.19%), germacrene D ( 5 ; 5.36%), and caryophyllene oxide ( 6 ; 5.37%) were the major essential oil constituents. This chemical composition differed from that previously reported for specimens harvested in Africa. Concerning the in vitro schistosomicidal activity against adult Schistosoma mansoni worms, PN‐EO was considered to be active, but less effective than the positive control praziquantel (PZQ) in terms of separation of coupled pairs, mortality, decrease in the motor activity, and tegumental alterations. However, PN‐EO caused an interesting dose‐dependent reduction in the number and the percentage of developed S. mansoni eggs. These results suggest that PN‐EO might be very promising for the development of new schistosomicidal agents.