Portal de Periódicos da CAPES

Acute Promyelocytic Leukemia After Iodine-131 Therapy for Graves' Disease

2005; Wiley; Volume: 25; Issue: 7 Linguagem: Inglês

10.1592/phco.2005.25.7.1017

1875-9114

Victor O. Kolade, Timothy J. Bosinski, Enrico L. Ruffy,

Thyroid Cancer Diagnosis and Treatment

Graves' disease is an autoimmune process in which the thyroid gland is stimulated by autoantibodies, leading to hyperthyroidism. Graves' disease is the most common cause of hyperthyroid function, primarily affecting women in their 40s and 50s. Treatment may involve oral radioiodine, which is taken up by the follicular cells of the thyroid, where it emits ionizing radiation to promote destruction of those cells. Radioiodine therapy is typically safe, effective, and inexpensive. We describe the case of a 51-year-old woman who developed acute promyelocytic leukemia within 27 months of completing a cumulative dose of radioiodine 22.1 mCi (817.7 MBq) for treatment of Graves' disease. Assessment of causality using the Naranjo probability scale showed that a possible relationship existed between this patient's acute promyelocytic leukemia and the use of radioiodine. Strict hematologic follow-up of patients treated with radioiodine may be warranted, along with a high index of suspicion in those with coagulopathy.