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In vitro screening of tumoricidal properties of international medicinal herbs: part II

2010; Wiley; Volume: 24; Issue: 12 Linguagem: Inglês

10.1002/ptr.3191

1099-1573

Elizabeth Mazzio, Karam F. A. Soliman,

Alkaloids: synthesis and pharmacology

Abstract With growing use of anticancer complementary and alternative medicines (CAMs) worldwide, there is a need to assess and screen commercially available natural products for relative tumoricidal properties under standard experimental conditions. In the current study, we screened and ranked 264 traditional Chinese and Egyptian herbal medicines for tumoricidal potency against malignant neuroblastoma in vitro . The data obtained show that tumoricidal potencies of plants were randomly dispersed throughout similar orders, families and genera under the Division: Magnoliophyta, class: Magnoliopsida, subclasses: Asteridae, Caryophyllidae, Dilleniidae, Hamamelididae, Magnoliidae and Rosidae. The most potent plant extracts (LC 50 < 0.08 mg/ml) were prepared from gromwell root also known as ‘Hong Tiao Zi Cao’ ( Lithospermum Erythrorhizon ) Family (Boraginaceae) > beth root ( Trillium Pendulum ), Family (Liliaceae) and galbanum ( Ferula Galbaniflua ), Family (Apiaceae). Gromwell root is traditionally used in the preparation of Chinese medicinal tea. In addition, galbanum was highly regarded for its sacred and medicinal value according to ancient texts and the bible. Future research will be required to isolate and identify chemical constituents within these plants which are responsible for tumoricidal effects. Copyright © 2010 John Wiley & Sons, Ltd.