Chemoenzymatic Approaches to Lycorine-Type Amaryllidaceae Alkaloids: Total Syntheses of ent -Lycoricidine, 3- epi - ent -Lycoricidine, and 4-Deoxy-3- epi - ent -lycoricidine
2007; American Chemical Society; Volume: 9; Issue: 18 Linguagem: Inglês
10.1021/ol701552r
ISSN1523-7060
AutoresMaria Matveenko, Okanya J. Kokas, Martin G. Banwell, Anthony C. Willis,
Tópico(s)Psychedelics and Drug Studies
ResumoThe readily available and enzymatically derived cis-1,2-dihydrocatechol 4 has been elaborated, over 11 steps including an Overman rearrangement, into the non-natural enantiomer, (−)-1, of the alkaloid lycoricidine [(+)-1]. Related chemistries have provided analogues 18, 19, and 26.
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