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Enhanced fluorescence imaging guided photodynamic therapy of sinoporphyrin sodium loaded graphene oxide

2014; Elsevier BV; Volume: 42; Linguagem: Inglês

10.1016/j.biomaterials.2014.11.040

1878-5905

Xuefeng Yan, Gang Niu, Jing Lin, Albert J. Jin, Hao Hu, Yuxia Tang, Yujie Zhang, Aiguo Wu, Jie Lü, Shaoliang Zhang, Peng Huang, Baozhong Shen, Xiaohong Chen,

Photodynamic Therapy Research Studies

Extensive research indicates that graphene oxide (GO) can effectively deliver photosensitives (PSs) by π-π stacking for photodynamic therapy (PDT). However, due to the tight complexes of GO and PSs, the fluorescence of PSs are often drastically quenched via an energy/charge transfer process, which limits GO-PS systems for photodiagnostics especially in fluorescence imaging. To solve this problem, we herein strategically designed and prepared a novel photo-theranostic agent based on sinoporphyrin sodium (DVDMS) loaded PEGylated GO (GO-PEG-DVDMS) with improved fluorescence property for enhanced optical imaging guided PDT. The fluorescence of loaded DVDMS is drastically enhanced via intramolecular charge transfer. Meanwhile, the GO-PEG vehicles can significantly increase the tumor accumulation efficiency of DVDMS and lead to an improved PDT efficacy as compared to DVDMS alone. The cancer theranostic capability of the as-prepared GO-PEG-DVDMS was carefully investigated both in vitro and in vivo. Most intriguingly, 100% in vivo tumor elimination was achieved by intravenous injection of GO-PEG-DVDMS (2 mg/kg of DVDMS, 50 J) without tumor recurrence, loss of body weight or other noticeable toxicity. This novel GO-PEG-DVDMS theranostics is well suited for enhanced fluorescence imaging guided PDT.