2-Hydroxycurcuminoid induces apoptosis of human tumor cells through the reactive oxygen species–mitochondria pathway
2010; Elsevier BV; Volume: 21; Issue: 2 Linguagem: Inglês
10.1016/j.bmcl.2010.11.114
ISSN1464-3405
AutoresYoung‐Min Han, Dae‐Seop Shin, Yujin Lee, Ismail Ahmed Ismail, Su‐Hyung Hong, Dong Cho Han, Byoung‐Mog Kwon,
Tópico(s)Genomics, phytochemicals, and oxidative stress
Resumo2-Hydroxycinnamaldehyde (HCA) and curcumin have been reported to have antitumor effects against various human tumor cells in vitro and in vivo by generation of ROS. Aldehyde-free HCA analogs were synthesized based on the structure of curcumin, which we have called 2-hydroxycurcuminoids. The hydroxyl group of curcuminoids enhances the ability to generate ROS. 2-Hydroxycurcuminoid (HCC-7) strongly inhibited the growth of SW620 colon tumor cells with a GI(50) value of 7μM, while the parent compounds, HCA and curcumin, displayed GI(50) values of 12 and 30μM, respectively. HCC-7 was found to induce apoptosis through the reactive oxygen species-mitochondria pathway and cell cycle arrest at G2/M phase.
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