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Pyridoxine and Riboflavin Status in the Paterson — Kelly Syndrome

1968; Wiley; Volume: 14; Issue: 2 Linguagem: Inglês

10.1111/j.1365-2141.1968.tb01484.x

1365-2141

Alice K. Jacobs, I. Cavill,

Connective tissue disorders research

S ummary A study of 25 patients with the Paterson‐Kelly syndrome shows them to have a normal red cell total riboflavin content. This suggests that riboflavin deficiency is not an important factor in this condition. There is a reduction of red cell transaminase activity which can be stimulated in vitro by pyridoxal phosphate. In three cases the administration of pyridoxine resulted in an in viva rise in red cell transaminase activity. Some degree of pyridoxine deficiency appears to be common in the Paterson‐Kelly syndrome.