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The synthesis of γ-substituted glutamic acids via a glutamic acid γ-enolate synthon

1994; Elsevier BV; Volume: 35; Issue: 34 Linguagem: Inglês

10.1016/s0040-4039(00)73426-5

1873-3581

Andrew N.C. Johnstone, Stefania Lopatriello, Michael North,

Fluorine in Organic Chemistry

Treatment of α-t-butyl γ-methyl N-Z-glutamate (4) with lithium hexamethyldisilazide results in the regiospecific formation of the γ-anion, which reacts with electrophiles to give γ-substituted glutamic acid derivatives.