Portal de Periódicos da CAPES

Carbamates in the chemotherapy of leukemia.V. observation of a possible antileukemic synergism between urethane and methyl-bis (β-chloroethyl) amine

1949; Wiley; Volume: 2; Issue: 3 Linguagem: Inglês

10.1002/1097-0142(194905)2

1097-0142

Howard E. Skipper,

Carcinogens and Genotoxicity Assessment

CancerVolume 2, Issue 3 p. 475-479 ArticleFree Access Carbamates in the chemotherapy of leukemia. V. observation of a possible antileukemic synergism between urethane and methyl-bis (β-chloroethyl) amine† Howard E. Skipper PH.D, Howard E. Skipper PH.D Biochemistry Division, Southern Research Institute, Birmingham, AlabamaSearch for more papers by this author Howard E. Skipper PH.D, Howard E. Skipper PH.D Biochemistry Division, Southern Research Institute, Birmingham, AlabamaSearch for more papers by this author First published: May 1949 https://doi.org/10.1002/1097-0142(194905)2:3 3.0.CO;2-3Citations: 15 † A nitrogen mustard often referred to by the code name HN2. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Berman, L., and Axelrod, A. R.: Effect of urethane on malignant diseases. Clinical, hematologic and histologic observations on patients with carcinoma, leukemia and related diseases. Am. J. Clin. Path. 18: 104– 129, 1948. 2 Boyland, E.: Chemical carcinogenesis and experimental chemotherapy of cancer. Yale J. Biol. & Med. 20: 321– 341, 1948. 3 Burchenal, J. H.; Rilev, J. B., and Lester, R. A.: Studies on the chemotherapy of transmitted leukemia in mice. International (4.) Cancer Research Congress, St. Louis, Mo., 1947, [Abstracts of Papers]. pp. 106– 107. 4 Burchenal, J. H.; Lester, R. A.; Riley, J. B., and Rhoads, C. P.: Studies on the chemotherapy of leukemia. I. Effect of certain nitrogen mustards and carbamates on transmitted mouse leukemia. Cancer 1: 399– 412, 1948. 5 Dustin, P.: Modifications de l'hematopoïese dans la leucemie myeloïde chronique traitée par le carbamate d'ethyle. Bruxelles-méd. 27: 1763– 1774, 1947. 6 Engstrom, R. M.; Kirschbaum, A., and Mixer, H. W.: Effect of urethane on mouse myelogenous leukemia. Science 105: 255– 256, 1947. 7 Fisher, R. A.: Statistical Methods for Research Workers, 10th ed. Edinburgh. Oliver and Boyd. 1948. 8 Flory, C. M.; Furth, J.; Saxton, J. A., Jr., and Reiner, L.: Chemotherapeutic studies on transmitted mouse leukemia. Cancer Research 3: 729– 743, 1943. 9 Goodman, M. J., and Lewis, H. P.: Urethane in leukemia. J.A.M.A. 132: 1105, 1946. 10 Goodman, L. S.; Wintrobe, M. M.; McLennan, M. T.; Dameshek, W.; Goodman, M. J., and Gilman, A.: Use of methyl-bis (d̃-chloroethyl) amine hydrochloride and tris (d̃-chloroethyl) amine hydrochloride (“nitrogen-mustards”) in the therapy of Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders. [A.A.A.S.] Approaches to Tumor Chemotherapy, 1947; pp. 338– 346. 11 Karnofsky, D. A.; Craver, L. F.; Rhoads, C. P., and Abels, J. C.: An evaluation of methylbis (β-chloroethyl) amine hydrochloride and tris (β-chloroethyl) amine hydrochloride (nitrogen mustards) in the treatment of lymphomas, leukemia and allied diseases. [A.A.A.S.] Approaches to Tumor Chemotherapy, 1947; pp. 319– 337. 12 Kracke, R. R.; Riser, W. H., Jr., and Stokes, G. H.: Paper presented at meeting of Alabama Medical Association, Mobile, Ala., 1948. Unpublished data. 13 Law, L. W.: Urethane therapy in spontaneous leukemias in mice. International (4.) Cancer Research Congress, St. Louis, Mo., 1947, [Abstracts of Papers]. p. 106. 14 Lu, C. S., and Kirschbaum, A.: Effect of urethane on normal and leukemic hemopoietic tissues of the mouse. International (4.) Cancer Research Congress, St. Louis, Mo., 1947, [Abstracts of Papers]. p. 105. 15 Maringer, S.: Urethan-Behandlung der Leukämie. Kasuistischer Beitrag. Schweiz. med. Wchnschr. 77: 114– 115, 1947. 16 Moeschlin, S.: Zum Wirkungsmechanismus des Urethans bei Leukämien. Helvet. med. acta 14: 279– 294, 1947. 17 Murphy, J. B., and Sturm, E.: The effect of urethane on lymphatic leukemia in rats. Science 104: 427, 1946. 18 Murphy, J. B., and Sturm, E.: The inhibiting effect of ethyl urethane on the development of lymphatic leukemia in rats. Cancer Research 7: 417– 420, 1947. 19 Paterson, E.; Haddow, A.; Ap Thomas, I., and Watkinson, J. M.: Leukaemia treated with urethane compared with deep x-ray therapy. Lancet 1: 677– 683, 1946. 20 Schulze, E.: Die Behandlung chronischer Leukämien mit Urethan. Deutsche med. Wchnschr. 72: 153– 157, 1947. 21 Schulze, E.; Fritze, E., and Muller, H. H.: Die Wirkung des Urethans bei Leukämien. Deutsche med. Wchnschr. 72: 371– 377, 1947. 22 Skipper, H. E., and Bryan, C. E.: Carbamates in the chemotherapy of leukemia. III. The relationship between chemical structure and anti leukemic action of a series of urethan derivatives. J. Nat. Cancer Inst. In press. 23 Southern Research Institute. Unpublished data. 24 Wintrobe, M. M.; McLennan, M. T., and Huguley, C. M., Jr.: Clinical experiences with nitrogen mustard therapy. [A.A.A.S.] Approaches to Tumor Chemotherapy. 1947; pp. 347– 357. Citing Literature Volume2, Issue3May 1949Pages 475-479 ReferencesRelatedInformation