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Genetics of neuronal migration in the cerebral cortex

2000; Wiley; Volume: 6; Issue: 1 Linguagem: Inglês

10.1002/(sici)1098-2779(2000)6

1098-2779

Christopher A. Walsh,

Microtubule and mitosis dynamics

Mental Retardation and Developmental Disabilities Research ReviewsVolume 6, Issue 1 p. 34-40 Genetics of neuronal migration in the cerebral cortex Christopher A. Walsh, Corresponding Author Christopher A. Walsh [email protected] Division of Neurogenetics, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MassachusettsDivision of Neurogenetics, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115Search for more papers by this author Christopher A. Walsh, Corresponding Author Christopher A. Walsh [email protected] Division of Neurogenetics, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MassachusettsDivision of Neurogenetics, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115Search for more papers by this author First published: 01 March 2000 https://doi.org/10.1002/(SICI)1098-2779(2000)6:1 3.0.CO;2-YCitations: 21AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract The development of the cerebral cortex requires large-scale movement of neurons from areas of proliferation to areas of differentiation and adult function in the cortex proper, and the patterns of this neuronal migration are surprisingly complex. The migration of neurons is affected by several naturally occurring genetic defects in humans and mice; identification of the genes responsible for some of these conditions has recently yielded new insights into the mechanisms that regulate migration. Other key genes have been identified via the creation of induced mutations that can also cause dramatic disorders of neuronal migration. However, our understanding of the physiological and biochemical links between these genes is still relatively spotty. A number of molecules have also been studied in mice (Reelin, mDab1, and the VLDL and ApoE2 receptors) that appear to represent part of a coherent signaling pathway that regulates migration, because multiple genes cause an indistinguishable phenotype when mutated. On the other hand, two human genes that cause lissencephaly (LIS1, DCX) encode proteins that have recently been implicated as regulators or microtubule dynamics. This article reviews some of the mutant phenotypes in light of the mechanisms of neuronal migration. MRDD Research Reviews 6:34–40, 2000. © 2000 Wiley-Liss, Inc. REFERENCES Anderson SA, Eisenstat DD, Shi L, et al. 1997. Interneuron migration from basal forebrain to neocortex: dependence on Dlx genes. Science 278: 474–476. Andressen C, Arnhold S, Puschmann M, et al. 1998. Beta1 integrin deficiency impairs migration and differentiation of mouse embryonic stem cell derived neurons. Neurosci Lett 251: 165–168. Anton ES, Kreidberg JA, Rakic P. 1999. 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