T cells in the pathogenesis of systemic lupus erythematosus
2004; Elsevier BV; Volume: 113; Issue: 1 Linguagem: Inglês
10.1016/j.clim.2004.05.001
ISSN1521-7035
Autores Tópico(s)Immune Cell Function and Interaction
ResumoRecent studies in patients with systemic lupus erythematosus (SLE) have demonstrated that autoantigen-reactive T cells can be isolated from peripheral blood and that such cells can support autoantibody production ex vivo, suggesting that they may have a central role in the pathogenesis of disease. In addition, recent work has identified and characterized signaling abnormalities in T cells from SLE that may be fundamental to the disease. This review will examine the role of T cells in the pathogenesis of SLE and it will consider pathogenic mechanisms by which T cells escape normal of immunological tolerance. The focus will be on recent studies characterizing autoantigen-reactive human T cells and signaling abnormalities identified in T cells from patients with SLE.
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