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Combinatorial Chemistry toward Understanding the Function(s) of Carbohydrates and Carbohydrate Conjugates

2001; Wiley; Volume: 7; Issue: 3 Linguagem: Francês

10.1002/1521-3765(20010202)7

ISSN

1521-3765

Autores

Angela Barkley, Prabhat Arya,

Tópico(s)

Chemical Synthesis and Analysis

Resumo

Chemistry – A European JournalVolume 7, Issue 3 p. 555-563 Concept Combinatorial Chemistry toward Understanding the Function(s) of Carbohydrates and Carbohydrate Conjugates Angela Barkley Dr., Angela Barkley Dr. Chemical Biology Program Steacie Institute for Molecular Sciences National Research Council of Canada 100 Sussex Drive, Ottawa, ON, K1A 0R6 (Canada) Fax (+1) 613-952-0068Search for more papers by this authorPrabhat Arya Prof. Dr., Prabhat Arya Prof. Dr. [email protected] Chemical Biology Program Steacie Institute for Molecular Sciences National Research Council of Canada 100 Sussex Drive, Ottawa, ON, K1A 0R6 (Canada) Fax (+1) 613-952-0068Search for more papers by this author Angela Barkley Dr., Angela Barkley Dr. Chemical Biology Program Steacie Institute for Molecular Sciences National Research Council of Canada 100 Sussex Drive, Ottawa, ON, K1A 0R6 (Canada) Fax (+1) 613-952-0068Search for more papers by this authorPrabhat Arya Prof. Dr., Prabhat Arya Prof. Dr. [email protected] Chemical Biology Program Steacie Institute for Molecular Sciences National Research Council of Canada 100 Sussex Drive, Ottawa, ON, K1A 0R6 (Canada) Fax (+1) 613-952-0068Search for more papers by this author First published: 26 January 2001 https://doi.org/10.1002/1521-3765(20010202)7:3 3.0.CO;2-ICitations: 35Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract The complexity and synthetic challenges of carbohydrate conjugates have resulted in a number of conceptual approaches to rapidly access sufficient quantities of these biomolecules (see figure for a carbohydrate conjugate building block with its potential diversity sites). This article summarizes these combinatorial approaches and also highlights fully automated library synthesis of carbohydrate conjugates, with the goals of understanding their biological roles. Abstract Combinatorial chemistry has contributed significantly to understanding the structure–function relationships of biologically important molecules such as proteins and nucleic acids. However, carbohydrates and carbohydrate conjugates, which have been identified as key modulators of several biological functions have not enjoyed the same measure of success. 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