Association of the APC Gene Product with β-Catenin
1993; American Association for the Advancement of Science; Volume: 262; Issue: 5140 Linguagem: Inglês
10.1126/science.8259518
ISSN1095-9203
AutoresBonnee Rubinfeld, Brian Souza, Iris Albert, Oliver Müller, Scott Chamberlain, Frank R. Masiarz, S Munemitsu, Paul Polakis,
Tópico(s)Helicobacter pylori-related gastroenterology studies
ResumoMutations in the human APC gene are linked to familial adenomatous polyposis and to the progression of sporadic colorectal and gastric tumors. To gain insight into APC function, APC-associated proteins were identified by immunoprecipitation experiments. Antibodies to APC precipitated a 95-kilodalton protein that was purified and identified by sequencing as beta-catenin, a protein that binds to the cell adhesion molecule E-cadherin. An antibody specific to beta-catenin also recognized the 95-kilodalton protein in the immunoprecipitates. These results suggest that APC is involved in cell adhesion.
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