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DNA immunization: a novel approach to allergen‐specific immunotherapy

1997; Wiley; Volume: 52; Issue: 10 Linguagem: Inglês

10.1111/j.1398-9995.1997.tb02415.x

1398-9995

Hans L. Spiegelberg, E. M. Orozco, Mark Roman, Eyal Raz,

Drug-Induced Adverse Reactions

AllergyVolume 52, Issue 10 p. 964-970 Free Access DNA immunization: a novel approach to allergen-specific immunotherapy H. L. Spiegelberg, Corresponding Author H. L. Spiegelberg Departments of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA, USAHans L. Spiegelberg, Department of Pediatrics 08333 University of California San Diego School of Medicine 9500 Gilman Drive La Jolla CA 92093-0833 USASearch for more papers by this authorE. M. Orozco, E. M. Orozco Departments of Medicine, University of California San Diego School of Medicine, La Jolla, CA, USASearch for more papers by this authorM. Roman, M. Roman Departments of Medicine, University of California San Diego School of Medicine, La Jolla, CA, USASearch for more papers by this authorE. Raz, E. Raz Departments of Medicine, University of California San Diego School of Medicine, La Jolla, CA, USASearch for more papers by this author H. L. Spiegelberg, Corresponding Author H. L. Spiegelberg Departments of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA, USAHans L. Spiegelberg, Department of Pediatrics 08333 University of California San Diego School of Medicine 9500 Gilman Drive La Jolla CA 92093-0833 USASearch for more papers by this authorE. M. Orozco, E. M. Orozco Departments of Medicine, University of California San Diego School of Medicine, La Jolla, CA, USASearch for more papers by this authorM. Roman, M. Roman Departments of Medicine, University of California San Diego School of Medicine, La Jolla, CA, USASearch for more papers by this authorE. Raz, E. Raz Departments of Medicine, University of California San Diego School of Medicine, La Jolla, CA, USASearch for more papers by this author First published: 29 April 2007 https://doi.org/10.1111/j.1398-9995.1997.tb02415.xCitations: 42AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat References 1 Adkinson NF, Eggleston PA, Eney D. et al. A controlled trial of immunotherapy for asthma in allergic children. N Engl J Med 1997; 336: 324– 31. 2 Ulmer JB, Donnelly JJ, Parker SE, et al. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 1993; 259: 1745– 9. 3 Fynan EF, Webster RG, Fuller DH, Haynes JR, Santoro JC, Robinson HL. DNA vaccines: protective immunization by parenteral. mucosal. and gene-gun inoculation. Proc Natl Acad Sci U S A 1993; 90: 11478– 82. 4 Manicken E, Rouse RJ, Yu Z, Wire WS, Rous BT. Genetic immunization against herpes simplex virus. J Immunol 1955; 155: 259– 65. 5 Raz E, Carson DA, Parker SE, et al. Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses. Proc Natl Acad Sci U S A 1994; 91: 9519– 23. 6 Pardaoll DM, Beckerleg AM. Exposing the immunology of naked DNA vaccines. Immunity 1995; 3: 165– 9. 7 Raz E, Tighe H, Sato Y, et al. Preferential induction of a Thl immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization. Proc Natl Acad Sci U S A 1996; 93: 5141– 5. 8 Coutelier JP, van der Logt JTM, Heessen WA, Waarner G, Van-Snick J. IgG2a restriction of murine antibodies elicited by viral infections. J Exp Med 1987; 165: 2373– 8. 9 Beck L, Spiegelberg HL. The polyclonal and antigen-specific IgE and IgG subclass response of mice injected with ovalburmin in alum or complete Freund's adjuvant. Cell Immunol 1989; 123: 1– 8. 10 Snapper CM, Paul WE. Interferon-β and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 1987; 236: 944– 7. 11 Mosmann TR, Coffman RL. The Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989; 7: 145– 73. 12 Parronchi P, Macchia D, Piccini MP, et al. Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production. Proc Natl Acad Sci U S A 1991; 88: 4538– 42. 13 Wierenga EA, Snock M, de Groot C, et al. Evidence for compartmentalization of functional subsets of CD4+ T lymphocytes in atopic patients. J Immunol 1990; 144: 4651– 6. 14 Hsu CH, Chua KY, Tao MH, et al. Immunoprophylaxis of allergen-induced immunoglobulin E synthesis and airway hyperresponsiveness in vivo by genetic immunization. Nat Med 1996; 2: 540– 4. 15 Slater JE, Zhang YJ, Arthur-Smith A, Colberg-Poley A. A DNA vaccine inhibits IgE responses to the latex allergen Hev b 5 in mice. J Allergy Clin Immunol 1997; 99: S504. 16 Sato Y, Roman M, Tighe H, et al. Immune-stimulatory DNA sequences necessary for effective intradermal gene immunization. Science 1996; 273: 352– 4. 17 Yamamoto S, Yamamoto T, Kataoka T, Kuramoto E, Yano O, Tokunaga T. Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN and IFN-mediated natural killer activity. J Immunol 1992; 148: 4072– 6. 18 Klinman DM, Yi AK, Beaucage SL, Conover J, Krieg AM. CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon y. Proc Natl Acad Sci U S A 1996; 93: 2879– 83. 19 Raz E, Roman M, Orozco EM, Carson DA. Immunostimulatory DNA sequences (ISS) are a Th1 promoting adjuvant. J Allergy Clin Immunol 1997; 99: S365. 20 Lee DJ, Tighe H, Roman M, Carson DA, Spiegelberg HL, Raz E. Inhibition of IgE antibody formation by plasmid DNA immunization is mediated by both CD4+ and CD8+ T cells. Int Arch Allergy Immunol 1997; 113: 227– 30. 21 Broide D, Orozco EM, Roman M, Carson DA, Raz E. Intradermal gene vaccination down-regulates both arms of the allergic response. J Allergy Clin Immunol 1997; 99: S129. 22 Hengge UR, Walker PS, Vogel JC. Expression of naked DNA in human, pig, and mouse skin. J Clin Invest 1996; 97: 2911– 16. Citing Literature Volume52, Issue10October 1997Pages 964-970 ReferencesRelatedInformation