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Artigo Acesso aberto Revisado por pares
BIBTEX RIS

Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development

2015; Elsevier BV; Volume: 125; Issue: 24 Linguagem: Inglês

10.1182/blood-2014-09-603803

ISSN

1528-0020

Autores

Kate L. Lowe, Brenda Finney, Carsten Deppermann, René Hägerling, Salomé L. Gazit, Jon Frampton, Christopher D. Buckley, Eric Camerer, Bernhard Nieswandt, Friedemann Kiefer, Steve P. Watson,

Tópico(s)

Barrier Structure and Function Studies

Resumo

Key Points Podoplanin and CLEC-2 critically drive the formation and integrity of developing cerebral blood vessels. Loss of cerebrovascular integrity is influenced by the loss of αIIb-mediated platelet aggregation and platelet secretion.

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