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Immunosuppressive cytokines (IL-10, TGF-β) genes expression in human gastric carcinoma tissues

1996; Wiley; Volume: 63; Issue: 4 Linguagem: Inglês

10.1002/(sici)1096-9098(199612)63

1096-9098

Takashi Morisaki, Mitsuo Katano, Akashi Ikubo, Keisei Anan, Mitsunari Nakamura, Kenjiro Nakamura, Hiroshi Sato, Masao Tanaka, Motomichi Torisu,

Colorectal and Anal Carcinomas

Journal of Surgical OncologyVolume 63, Issue 4 p. 234-239 Immunosuppressive cytokines (IL-10, TGF-β) genes expression in human gastric carcinoma tissues Takashi Morisaki MD, Corresponding Author Takashi Morisaki MD Division of Clinical Immunology, First Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, JapanDivision of Clinical Immunology, First Department of Surgery, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812, JapanSearch for more papers by this authorMitsuo Katano MD, Mitsuo Katano MD Department of Surgery, Saga Medical School, Saga, JapanSearch for more papers by this authorAkashi Ikubo MD, Akashi Ikubo MD Division of Clinical Immunology, First Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, JapanSearch for more papers by this authorKeisei Anan MD, Keisei Anan MD Division of Clinical Immunology, First Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, JapanSearch for more papers by this authorMitsunari Nakamura MD, Mitsunari Nakamura MD Department of Surgery, Saga Medical School, Saga, JapanSearch for more papers by this authorKenjiro Nakamura, Kenjiro Nakamura Division of Clinical Immunology, First Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, JapanSearch for more papers by this authorHiroshi Sato MD, Hiroshi Sato MD Division of Clinical Immunology, First Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, JapanSearch for more papers by this authorMasao Tanaka MD, Masao Tanaka MD Division of Clinical Immunology, First Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, JapanSearch for more papers by this authorMotomichi Torisu MD, Motomichi Torisu MD Division of Clinical Immunology, First Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, JapanSearch for more papers by this author Takashi Morisaki MD, Corresponding Author Takashi Morisaki MD Division of Clinical Immunology, First Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, JapanDivision of Clinical Immunology, First Department of Surgery, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812, JapanSearch for more papers by this authorMitsuo Katano MD, Mitsuo Katano MD Department of Surgery, Saga Medical School, Saga, JapanSearch for more papers by this authorAkashi Ikubo MD, Akashi Ikubo MD Division of Clinical Immunology, First Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, JapanSearch for more papers by this authorKeisei Anan MD, Keisei Anan MD Division of Clinical Immunology, First Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, JapanSearch for more papers by this authorMitsunari Nakamura MD, Mitsunari Nakamura MD Department of Surgery, Saga Medical School, Saga, JapanSearch for more papers by this authorKenjiro Nakamura, Kenjiro Nakamura Division of Clinical Immunology, First Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, JapanSearch for more papers by this authorHiroshi Sato MD, Hiroshi Sato MD Division of Clinical Immunology, First Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, JapanSearch for more papers by this authorMasao Tanaka MD, Masao Tanaka MD Division of Clinical Immunology, First Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, JapanSearch for more papers by this authorMotomichi Torisu MD, Motomichi Torisu MD Division of Clinical Immunology, First Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, JapanSearch for more papers by this author First published: December 1996 https://doi.org/10.1002/(SICI)1096-9098(199612)63:4 3.0.CO;2-DCitations: 28AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Background Contribution of immunosuppressive cytokines to tumor progression in many types of cancers has been suggested. To characterize the in vivo expression of immunosuppressive cytokines in gastric cancer, we analyzed the messenger RNA (mRNA) expression of transforming growth factor-β (TGF-β) and interleukin-10 (IL-10) in human gastric carcinoma tissues. Methods Both tumor tissues and nontumor tissues from each resected specimen of 29 primary gastric carcinomas were tested for IL-10 and TGF-β mRNA expression by the reverse transcriptase-polymerase chain reaction (RT-PCR), and the mRNA expression was correlated with various pathological parameters of the tumors. Results Among the 29 tumors, mRNAs of TGF-β and IL-10 were detected in 79% and 62% of tumor samples, respectively. These cytokines were detected only in 31% for TGF-β and 17% for IL-10 in nontumor samples. Both mRNAs were frequently expressed in the poorly differentiated adenocarcinomas and the tumor tissues with high degree of stage or lymphnode metastasis. Conclusions Local expression of immunosuppressive cytokines may contribute to the progression of primary gastric carcinomas possibly through immunosuppression. © 1996 Wiley-Liss, Inc. Citing Literature Volume63, Issue4December 1996Pages 234-239 RelatedInformation