Striking a balance in maternal immune response to infection
1998; Elsevier BV; Volume: 351; Issue: 9117 Linguagem: Inglês
10.1016/s0140-6736(98)22023-x
ISSN1474-547X
Autores Tópico(s)COVID-19 Impact on Reproduction
ResumoThe survival of the fetus as an "allograft" in pregnancy has promulgated a longstanding, widely held belief that a woman's immune responsiveness is depressed during pregnancy. Were this the case, one might predict an increased incidence of maternal infection and a predisposition to severe or widely disseminated infection, with disastrous consequences for the fetus, which, if repeated on a global scale, could endanger the survival of the species. Postpartum comaA previously healthy 33-year-old woman was referred to the Liver Unit, in April, 1997, 4 days post partum. She had become confused 12 h after a normal delivery and was in grade IV coma on transfer. Her International Normalised Ratio was 5·2, albumin 190 g/L, bilirubin 87 μmol/L, alkaline phosphatase (AP) 145 IU/L, γ-glutamyl transpeptidase (GGT) 23 IU/L, aspartate aminotransferase (AST) 490 IU/L, alanine aminotransferase (ALT) 162 IU/L. Hepatitis virus and HIV-1 serology were negative. Ultrasound scanning showed a normal-sized liver with diffusely increased echogenicity. Full-Text PDF
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