Pharmacokinetics and antisecretory effects of intravenous omeprazole in horses
1992; Wiley; Volume: 24; Issue: S13 Linguagem: Inglês
10.1111/j.2042-3306.1992.tb04794.x
ISSN2042-3306
AutoresChristine C. Jenkins, Donita L. Frazier, J. T. Blackford, Frank M. Andrews, H. Mattsson, S.‐G. Olovsson, Margaret McCleod,
Tópico(s)Veterinary medicine and infectious diseases
ResumoSummary Eight young female horses with chronic gastric cannulae received 0.5 mg omeprazole/kg bwt iv once daily for 5 consecutive days. Gastric secretion was measured on the 1st and 5th day. Basal secretion was determined 1 h before and 1 h after the omeprazole dose, followed by pentagastrin stimulation for 2 h. Gastric juice samples were collected from the cannula every 15 mins for the determination of volume, pH, acidity, and acid outputs. As control, sterile water was similarly administered to all 8 horses. Pharmacokinetic evaluation of intravenous omeprazole was determined concurrently on the 1st and 5th day of administration. Omeprazole reduced both basal and stimulated acid output (mmol H + /h) by more than 90%, with a significant increase in gastric juice pH both on the 1st and 5th day of administration. A trend suggesting a long duration of inhibitory action was observed 23 h after the 4th dose of omeprazole since 58% of gastric acid output was inhibited. Thus omeprazole shows potential as a once a day antisecretory drug in horses. Plasma omeprazole concentration versus time profiles were best described using a two‐compartment model. There was no statistical difference between the pharmacokinetic disposition of omeprazole on Days 1 and 5. The elimination half‐life of intravenous omeprazole was about 30 mins.
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