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Artigo Revisado por pares
BIBTEX RIS

Cocaine withdrawal in Planaria

2001; Elsevier BV; Volume: 430; Issue: 1 Linguagem: Inglês

10.1016/s0014-2999(01)01358-9

ISSN

1879-0712

Autores

Robert B. Raffa, Joseph M. Valdez,

Tópico(s)

Photoreceptor and optogenetics research

Resumo

Cocaine-exposed planarians displayed abstinence-induced withdrawal behavior when placed into cocaine-free, but not cocaine-containing, water. The effect, manifested and quantified using a new spontaneous locomotor velocity metric, was dose-dependently related to cocaine exposure (8x10(-9) to 8x10(-5) M). Ultraviolet light (254 nm=7.83x10(-19) J), which was previously shown to interfere with drug-receptor interactions in Planaria, enhanced the abstinence-induced decreased locomotor velocity.

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