Aminoácidos libres en liquido cefalorraquídeo de recién nacidos con encefalopatía hipóxico isquémica
1994; Elsevier BV; Volume: 65; Issue: 4 Linguagem: Inglês
10.4067/s0370-41061994000400002
ISSN0717-6228
AutoresJorge Rodríguez O., Ximena Lecaros G, Magdalena Cortés Saavedra,
Tópico(s)Mitochondrial Function and Pathology
ResumoFree aminoacids in the cerebrospinal fluid of newborn infants with hipoxic ischemic encephalopathyCerebrospinal fluid free aminoacid (AA| composition depends on blood -CSF barrier, nervous tissue and ependima captation.It has been previously reported that in mammalian cerebral cortex a decrease of adenosinetriphosphate (ATP) is associated with an increase in asparlic acid, a deciease in glutarnic acid, aminobulyric acid and glutamine contents and that fuel deprivation causes changes in brain levels of ATP and those mentioned aminoacids.Using gas cromatography, after isobuthanol sterification of the carboxilic group and heptafluorbulyrate acylation of the amino group, free aminoacid content of cerebrospinal fluid and plasma were studied in eighl normal canlrol newborn infants and eight patients with neonatal hipoxic ischemic encephalopathy in order to detect changes in these late, but no differences of aminoacid concentration in cerebrospinal fluid were recorded among both groups.This result is in contradiction with recent reports of increased excitatory aminoacid (glutamic and aspartic acid) concentration in the cerebrospinal fluid of six asphyxiated newborn infants, and of a good ccxfelalion of these changes and neurologic prognosis of patients.More experience is needed in these respecl.
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