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Haemocompatibility of polymer having phospholipid polar groups evaluated by monoclonal antibody method

1992; Elsevier BV; Volume: 13; Issue: 6 Linguagem: Inglês

10.1016/0142-9612(92)90040-u

1878-5905

Tingfei Xi, Wenhua Tian, Lei Xue-Hui, Lejun Zhao, Kazuhíko Ishihara,

Antimicrobial agents and applications

The haemocompatibility of a polymer having the phospholipid polar group, poly(2-methacryloyloxyethyl phosphorylcholine (MPC)-co-n-butyl methacrylate(BMA)), was evaluated by a monoclonal antibody SZ-21 (directing specifically against the membrane glycoprotein complex IlIa of human platelet) radioimmunoassay method. The study showed that poly(MPC-co-BMA) possessed better haemocompatibility than segmented polyurethane (SPEU). Radioactivity of platelets adhered (counts per min/cm) on a polyethylene (PE) tube coated with poly(MPC-co-BMA) was 19.51 ± 5.58, with albumin; 20.05 ± 7.29, with SPEU having sulphonated group; 76.10 ± 18.9, with SPEU; 287.0 ± 95.0, PE treated by plasma irradiation; 2091 ± 261, and original PE was 1772 ± 116. The results were further certified by scanning electron microscopic observations.