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Activity-dependent neuronal signalling and autism spectrum disorder

2013; Nature Portfolio; Volume: 493; Issue: 7432 Linguagem: Inglês

10.1038/nature11860

1476-4687

Daniel H. Ebert, Michael E. Greenberg,

Signaling Pathways in Disease

Neuronal activity induces the post-translational modification of synaptic molecules, promotes localized protein synthesis within dendrites and activates gene transcription, thereby regulating synaptic function and allowing neuronal circuits to respond dynamically to experience. Evidence indicates that many of the genes that are mutated in autism spectrum disorder are crucial components of the activity-dependent signalling networks that regulate synapse development and plasticity. Dysregulation of activity-dependent signalling pathways in neurons may, therefore, have a key role in the aetiology of autism spectrum disorder.