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Methionine metabolism in mammals: Regulatory effects of S-adenosylhomocysteine

1974; Elsevier BV; Volume: 165; Issue: 2 Linguagem: Inglês

10.1016/0003-9861(74)90306-3

1096-0384

James D. Finkelstein, Walter E. Kyle, Barbara J. Harris,

Cancer Research and Treatments

S-Adenosylhomocysteine inhibits betaine-homocysteine methyltransferase. The inhibition is nonlinear, competitive in relation to homocysteine, and noncompetitive in relation to betaine. S-Adenosylhomocysteine activates cystathionine synthase at all concentrations of the substrates, serine and homocysteine. By altering the distribution of homocysteine between these competing pathways, S-adenosylhomocysteine may be significant in the regulation of methionine metabolism in the intact animal.