Portal de Periódicos da CAPES

One‐Pot Synthesis of Tagatose 1,6‐Bisphosphate by Diastereoselective Enzymatic Aldol Addition

1992; Wiley; Volume: 31; Issue: 1 Linguagem: Inglês

10.1002/anie.199200561

1521-3773

Wolf‐Dieter Fessner, Oliver Eyrisch,

Pancreatic function and diabetes

A new aldolase from E. coli, the D-tagatose-1,6-bisphosphate-aldolase (TagA), catalyzes the asymmetric addition of dihydroxyacetone phosphate to D-glycerinaldehyde-3-phos-phate, which can be used for the efficient synthesis of the bisphosphate 1 of the rare carbohydrate metabolite D-tagatose. A 4-epimer formed as a byproduct in small amounts can be removed easily from the mixture of products by subsequent specific enzymatic reactions.