Some recent applications of α-amino nitrile chemistry
2000; Royal Society of Chemistry; Volume: 29; Issue: 5 Linguagem: Inglês
10.1039/a908290e
ISSN1460-4744
AutoresDieter Enders, John P. Shilvock,
Tópico(s)Advanced Synthetic Organic Chemistry
ResumoBifunctional α-amino nitriles are not only versatile intermediates in organic synthesis but also exhibit a valuable dual reactivity, which has been utilized in a broad range of synthetic applications. This review highlights recent developments in the chemistry of α-amino nitriles, including asymmetric synthesis of α-amino acids via Strecker reactions using chiral auxiliaries and catalysts, α-amino nitriles as masked iminium ion equivalents in cationic reactions and the synthesis of natural products and heterocycles, and α-metallation to provide nucleophilic acyl anion equivalents and applications to asymmetric Umpolung reactions.
Referência(s)