Effect of low-dose heparin on urinary albumin excretion in insulin-dependent diabetes mellitus
1995; Elsevier BV; Volume: 345; Issue: 8947 Linguagem: Inglês
10.1016/s0140-6736(95)90403-4
ISSN1474-547X
AutoresBjarne Myrup, Pernille M. Hansen, Allan Kofoed‐Enevoldsen, Bo Feldt‐Rasmussen, T. Deckert, T. Jensen, Jørgen Jespersen, Cornelis Kluft,
Tópico(s)Diabetes and associated disorders
ResumoWe investigated the effect of heparin on urinary albumin excretion in patients with insulin-dependent diabetes mellitus. 39 patients with persistent urinary albumin excretion of 30-300 mg/24 h were randomly treated for 3 months with subcutaneous injections twice daily of isotonic saline, 5000 IU unfractionated heparin, or 2000 anti-Xa IU low-molecular-weight heparin. Unfractionated and low-molecular-weight heparin induced a significant reduction in urinary albumin excretion (p=0·04 and p=0·004). The mechanism and clinical relevance is unknown but deserve further attention.
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