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Artigo Revisado por pares
BIBTEX RIS

Enantioselective -Amino Acid Synthesis Based on Catalyzed Asymmetric Acyl Halide – Aldehyde Cyclocondensation Reactions

2000; Wiley; Volume: 39; Issue: 7 Linguagem: Inglês

10.1002/(sici)1521-3773(20000403)39

ISSN

1521-3773

Autores

Scott G. Nelson, Keith L. Spencer,

Tópico(s)

Synthetic Organic Chemistry Methods

Resumo

N-Protected β-amino acids are obtained from an operationally simple, two-step enantioselective synthesis, which integrates aluminum-catalyzed asymmetric acyl halide – aldehyde cyclocondensation reactions with amine-mediated SN2 ring opening of the derived enantiomerically enriched β-lactones (see scheme).

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