Time to rethink TNM staging in cutaneous SCC
2008; Elsevier BV; Volume: 9; Issue: 8 Linguagem: Inglês
10.1016/s1470-2045(08)70185-2
ISSN1474-5488
Autores Tópico(s)Cutaneous Melanoma Detection and Management
ResumoNon-melanoma skin cancer (NMSC) is the most common malignancy worldwide, with about 20% of NMSC classified as squamous-cell carcinoma (SCC). Most arise on the sun-exposed head and neck in older white men as a consequence of chronic, often occupational, sun exposure. In countries such as Australia, these cancers are at an epidemic rate and associated with morbidity and mortality. Although only a few ( 20 mm) •Thick or deeply invasive lesion (>4–5 mm) •Incomplete excision •Recurrent setting •High-grade or desmoplastic growth •Presence of perineural invasion •Presence of lymphovascular invasion •Located near the parotid gland (eg, ear, temple, forehead, or anterior scalp) •Immunosuppressed state (eg, transplant recipient or haematological malignancy) •Rapid growth •Large size (>20 mm) •Thick or deeply invasive lesion (>4–5 mm) •Incomplete excision •Recurrent setting •High-grade or desmoplastic growth •Presence of perineural invasion •Presence of lymphovascular invasion •Located near the parotid gland (eg, ear, temple, forehead, or anterior scalp) •Immunosuppressed state (eg, transplant recipient or haematological malignancy) •Rapid growth Analysis of risk factors determining prognosis of cutaneous squamous-cell carcinoma: a prospective studyOnly SCC greater than 2·0 mm in thickness are associated with a significant risk of metastasis. Tumours greater than 6·0 mm are associated with a high risk of metastasis and local recurrence. Desmoplastic growth is an independent risk factor for local recurrence. Studies should assess the role of follow-up visits and sentinel-lymph-node biopsy in high-risk patients. Full-Text PDF
Referência(s)