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Hastifolins A–G, antifeedant neo-clerodane diterpenoids from Scutellaria hastifolia

2010; Elsevier BV; Volume: 71; Issue: 17-18 Linguagem: Inglês

10.1016/j.phytochem.2010.08.021

1873-3700

Rosa Angela Raccuglia, Gabriella Bellone, Kristina Ložienė, Franco Piozzi, Sergio Rosselli, Antonella Maggio, Maurizio Bruno, Monique S. J. Simmonds,

Natural product bioactivities and synthesis

From the aerial parts of Scutellaria hastifolia, family Lamiaceae (Labiatae), seven neo-clerodane diterpenoids (hastifolins A–G) were isolated. The products are similar to the known scuteparvin and are characterized by being trans-cinnamoyl derivatives. Structures and stereochemistry were determined by intensive NMR investigation. Six of the products form three pairs of epimers at C-13. Hastifolins A–C showed significant antifeedant activity.