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Elevated Plasma Levels of Interleukin-1 Receptor Antagonist are Associated with Decreased Cellular BCL-2 Oncoprotein Expression in B-Chronic Lymphocytic Leukemia

1998; Mary Ann Liebert, Inc.; Volume: 13; Issue: 5 Linguagem: Inglês

10.1089/cbr.1998.13.383

1557-8852

Anette Duensing, A. Nasarek, Jens Grosse, Arnold Ganser, Jens Atzpodien,

Lymphoma Diagnosis and Treatment

Plasma IL-1Ra levels and cellular BCL-2 oncoprotein expression were measured in a total of forty blood samples obtained from twenty-eight B-CLL patients and four healthy subjects. High IL-1Ra plasma levels (as defined by mean + three times standard deviation of normal controls) were observed in eleven samples (ten patients) which showed a significantly decreased cellular expression of BCL-2 protein (14.7±16.3%) of cells as determined by immunofluorescence) when compared to B-CLL samples with no elevated IL-1Ra (BCL-2, 31.0±18.6%; p≤0.0115). Albeit correlational only, our results may encourage further experiments to elucidate potential regulatory effects of IL-1Ra for cellular BCL-2 oncoprotein expression.