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Heparin-independent, PF4-dependent binding of HIT antibodies to platelets: implications for HIT pathogenesis

2014; Elsevier BV; Volume: 125; Issue: 1 Linguagem: Inglês

10.1182/blood-2014-06-580894

1528-0020

Anand Padmanabhan, Curtis G. Jones, Daniel W. Bougie, Brian R. Curtis, Janice G. McFarland, Demin Wang, Richard H. Aster,

Venous Thromboembolism Diagnosis and Management

Key Points Platelet-activating, but not nonactivating, human HIT antibodies bind to and activate PF4-treated platelets. Activating antibodies may recognize subtle conformational changes induced in PF4 by chondroitin-4-sulfate, the major platelet glycosaminoglycan.